mTOR, or mechanistic target of rapamycin, is a large protein kinase and a crucial sensor of cellular anabolic processes. mTOR signalling regulates a wide variety of cellular functions, including growth control, mitochondrial function, autophagy and lipid synthesis.
Activation of mTOR signalling also causes neurological diseases associated with epilepsy, autism spectrum disorders and intellectual disability.
We are interested in understanding the role of mTOR in nervous system development and how activation of mTOR signalling causes neurological disease.
In the long term, understanding how mTOR contributes to neurological disease will lead to new treatments for these devastating diseases.